Dr. Kobi Rosenblum

 

Tel: 972-4-8288421

Fax: 972-4-8240966

E-mail: kobir@psy.haifa.ac.il

 

Short CV:

Education

 

1992 - 1996      Ph.D. in Neurobiology from the Feinberg Graduate School, Weizmann  Institute of Science.

 

1990 - 1991      M.Sc. in Neurobiology from the Feinberg Graduate School, Weizmann Institute of Science.

 

1986 - 1989       B.Sc. in biology from Tel-Aviv University, Tel-Aviv, Israel.

 

 

Employment in Academy

 

November 2000    present Senior lecturer in the Center for Brain and Behavior, Haifa University.

 

1998 - 2000         Research Associate in the department of Neurophysiology, N.I.M.R., London (Royal Society Fellow). 

        

1996 -1998          Post doctorate research in Prof. Bliss's laboratory in the N.I.M.R., London (EMBO long-term Fellow).

 

Research Interest:

We are interested in biological mechanisms of learning and memory. We aim to understand how memories are being formed and maintained and how memories are faded over time (forgetting).

 We are using a combination of biological techniques including molecular biology, biochemistry, cellular imaging, electrophysiology, neuroanatomy and behavior in order to understand the molecular and cellular mechanisms of memory formation and consolidation. Recently, we found the involvement of specific proteins in memory consolidation (e.g. elongation factor-2 and MAPK). We try to understand the specific role of these proteins in learning processes.  The research in the laboratory contributes to the growing understanding of how memories are being formed in the normal brain.  In addition, the research may explain the biological mechanisms of memory and learning deficits in the case of aging and diseases.

 

Selected publications:

Rosenblum K., Dudai Y. and Richter-Levine G. (1996) LTP increases tyrosine phosphorylation of the N-methyl-D-aspartate receptor in the rat dentate gyrus in vivo. Proc. Natl. Acad. Sci. USA. 93 10457-10460.

 

Rosenblum K., Berman D., Hazvi S., and Dudai Y. (1997) NMDA receptor and the tyrosine phsophorylation of its 2B subunit in taste learning in the rat insular cortex. Journal of Neuroscience 17 (13) 5129-5135.

 

Jones M., French P., Bliss TVP and Rosenblum K (1999). Molecular mechanisms of LTP in the insular cortex. Journal of Neuroscience 19 RC36 1-8.

 

 Rosenblum K., Futter M., Jones M., Hulme ED., and Bliss TVP (2000). ERKI/II regulation by the muscarinic acetylcholine receptors in neurones. Journal of Neuroscience 20 (3) 977-985.

 

Rosenblum K., Futter M., Voss K., Skehel PA., French P., Obosi L and Bliss TVP (2002). The role of ERKI/II in late phase LTP. Journal of Neuroscience 22 (13) 5432-41.

Research Projects:

 

  1. Identifying the cortical circuit subserving a given memory using advanced microscopy.
  2. Identifying proteins and post translation modifications that take part in neuronal modifications subserving memory formation.
  3. Proteomics approach to study the role of MAPK in learning and memory.
  4. Identifying the role of translation regulation in memory consolidation.
  5. Molecular mechanisms of role learning (in collaboration with Dr. Edi Barkai).
  6. Biological mechanisms of taste memory in the taste cortex.
  7. Biological mechanisms of LTP consolidation (late phase LTP).
  8. Integration of modulatory and fast neurotransmission on the molecular level.

 

Research students:

 

PhD students

Alina Alkobi

Hanoch Kapzan (MD)           

Katia Katz                   

 

MSc students                      

Shelly Cuulman           

Guy Doron                   

Rinat Levi